{"id":87,"date":"2013-07-19T08:09:39","date_gmt":"2013-07-19T13:09:39","guid":{"rendered":"https:\/\/wp.stolaf.edu\/chemistry\/?page_id=87"},"modified":"2013-07-19T08:09:39","modified_gmt":"2013-07-19T13:09:39","slug":"gene-regulation-by-rna-riboswitches","status":"publish","type":"page","link":"https:\/\/wp.stolaf.edu\/chemistry\/gene-regulation-by-rna-riboswitches\/","title":{"rendered":"Gene Regulation by RNA Riboswitches"},"content":{"rendered":"<div data-modular-content-collection><p><strong><a href=\"mailto:muth@stolaf.edu\">Greg Muth<\/a>\u00a0\u2013<\/strong>Associate Professor and Chair of Chemistry Department<\/p>\n<p>Student Researchers<br \/>\nJames Checco<br \/>\nKate Helmich<\/p>\n<table style=\"width: 410px\" border=\"0\">\n<tbody>\n<tr>\n<td width=\"392\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" src=\"https:\/\/wp.stolaf.edu\/chemistry\/files\/2013\/07\/muthresearch09.jpg\" width=\"392\" height=\"294\" \/><\/td>\n<td width=\"196\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Recent advances in genomics, the mapping of genes and their functions, have provided a wealth of information for researchers.\u00a0 One of the areas that has benefited is the study of gene regulation, the ability of an organism to selectively turn off and on certain genes in response to environmental conditions or at specific times during its lifecycle.\u00a0 Of particular interests are short sequences of mRNA upstream of some genes that are sensitive to the intercellular concentration of certain metabolites.\u00a0 The metabolites appear to bind to and alter the structure of the mRNA.\u00a0 This conformational change affects the transcription and or translation process thus switching the gene either on or off.\u00a0 To better understand the details of these RNA &#8220;riboswitches&#8221;, we are studying the purine riboswitch using a variety of biochemical and biophysical techniques.<\/p>\n<p>The project utilizes interdisciplinary techniques from biochemistry, microbiology, genetics, cell biology and bioinformatics.\u00a0 We will be working jointly with members of Prof. Schwinefus&#8217;s team.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Greg Muth\u00a0\u2013Associate Professor and Chair of Chemistry Department Student Researchers James Checco Kate Helmich Recent advances in genomics, the mapping of genes and their functions, have provided a wealth of [&hellip;]<\/p>\n","protected":false},"author":209,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-87","page","type-page","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/pages\/87","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/users\/209"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/comments?post=87"}],"version-history":[{"count":0,"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/pages\/87\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.stolaf.edu\/chemistry\/wp-json\/wp\/v2\/media?parent=87"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}