Francesca Anderegg holds a Bachelor of Arts from Harvard University and masters' and doctoral degrees from The Juilliard School, where her teachers included Robert Mann, Ronald Copes, and Naoko Tanaka. She is a laureate of the Corpus Christi Competition and winner of fellowships from both the McKnight Foundation and the Leonore Annenberg Fund. An enthusiastic educator and mentor of young musicians, Anderegg is Associate Professor of Violin at St. Olaf College and has taught at Interlochen Center for the Arts.

Since her Carnegie Hall debut in 2008, Anderegg has given recitals in national and international venues, including Brooklyn's National Sawdust, the National Museum of Colombia in Bógota, concert halls throughout Brazil during her tour as a U.S. Embassy-sponsored artistic ambassador, Chicago’s Symphony Center, the Metropolitan Museum of Art with Itzhak Perlman and members of the Perlman Music Program, and many others across the world. Her three solo albums have been noted for their “lustrous tone” (The Strad Magazine) and “riveting listening experience” (Second Inversion).

The search for unusual repertoire has made Anderegg a fierce advocate for new music. She made her 2007 New York concerto debut performing Ligeti’s Violin Concerto with The Juilliard Orchestra and has performed Pierre Boulez's solo compositions under the direction of the composer at the Lucerne Festival in Switzerland. With composer Reinaldo Moya, Anderegg has performed a series of original works exploring magical realism and other elements of Latin American literature and imagination. In August 2019, she gave the world premiere of Moya's violin concerto, in collaboration with conductor Gemma New. In 2020, Francesca has been reaching audiences via the ImmerSphere performance platform, a new format combining augmented/virtual/mixed realities with live performance. She is the first violinist ever to perform using this combination of technologies.